Volume 7 ; Issue 1 ; in Month : Jan-June (2024) Article No : 150
Mittal L, Gupta N, Srivastava R, et al.

Abstract

Background: Gastrointestinal (GI) abnormalities are concurrent symptoms that are commonly found in children with autism. They possess a lower overall abundance of beneficial taxa, in the GI microbiota. Prebiotics, such as Inulin & Human milk oligosaccharides (HMO) promote the growth of beneficial bacteria such as Bifidobacteria, in the GI tract and provide numerous health benefits. Therefore, this study was undertaken to compare the beneficial effects of Inulin and Human Milk Oligosaccharides (HMO) in managing gut health issues in autistic children age group 4-10 years. Materials and Methods: This was an open randomized trail undertaken from December 2022 to May 2023. Sixty children diagnosed with autism with gut-related issues with ROME III criteria were enrolled in the study and randomly divided into two groups. Group A received 1 gram of HMO daily and Group B received 0.8 grams of inulin daily for 12 weeks. Ethical clearance was obtained, and study is registered with Clinical Trial Registry of India. Informed consent was obtained from the parents of the children before enrolment. Data at baseline and at the end of 12 weeks were collected. Total Score between two interventions was analyzed by using student test and comparison of each GI symptoms was done by Mann-Whitney U test. P value less than 0.05 was considered ads significant. Results: There was significant difference between the mean values of the total scores on ROME Criteria III of Inulin and HMO groups at baseline and at the end of 12 weeks of the intervention (p <0.001*** and p <0.001***, respectively). Conclusion: HMO showed better outcomes than inulin in the treatment of GI dysfunction in children with autism.

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