Volume 9 ; Issue 1 ; in Month : Jan-June (2026) Article No : 176
Mandal RK, Pandey A, Priya M, et al.

Abstract

Tuberculosis remains a major global health burden, further complicated by prolonged treatment regimens, poor patient adherence and the emergence of multidrug-resistant strains. These challenges highlight the urgent need for advanced drug delivery approaches. The present review aims to evaluate the potential of phytoliposome based targeted drug delivery systems in improving TB therapy. A comprehensive narrative review methodology was adopted, analyzing literature published between 2010 to 2025 from scientific databases including PubMed, Scopus and Google Scholar. Phytoconstituents such as alkaloids, flavonoids and terpenoids exhibit significant antimycobacterial activity but suffer from poor bioavailability and pharmacokinetic limitations. Phytoliposomes, formed by complexation of phytochemicals with phospholipids, enhance solubility, stability and intracellular delivery, particularly to macrophages harbouring Mycobacterium tuberculosis. Key findings indicate a 2-5 fold improvement in drug efficacy, enhanced bioavailability, controlled release and reduced systemic toxicity. Targeted delivery strategies including ligand-mediated systems, further improve therapeutic outcomes and reduce drug resistance. In conclusion, phytoliposome based drug delivery systems represent a promising and innovative approach for TB management. Their ability to enhance drug performance and enable targeted therapy suggests strong potential for future clinical applications, particularly in addressing resistant and latent TB infections.

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