]> Nagavalli D, Abirami G, Cheran V, et al. Volume 8 Issue 1 2581-4745 10.31531/2581-4745.1000158 This study aims to perform molecular docking of various miconazole derivatives against antifungal proteins 8VLK and 4UYL using ArgusLab and AutoDock Additionally MolInspiration software is utilized to predict the ADMET Absorption Distribution Metabolism Excretion and Toxicity properties of these compounds Azole derivatives are wellknown antifungal agents that function by inhibiting ergosterol synthesis in the fungal cell membrane Fifty miconazole derivatives have been identified using ChemSketch software and their novelty has been confirmed through PubChem ensuring that these compounds do not already exist The study compares the binding energy of these derivatives with that of the original miconazole drug to identify potential candidates with lower energy reduced toxicity or enhanced antifungal potency All Published Work is Licensed under a creative commons attribution 4.0 international license 2025