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<title>International-Journal-of-Biomedical-Investigation-ISSUE VOLUME Volume 2 ISSUE Issue 1</title>
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<description>
International-Journal-of-Biomedical-Investigation: VOLUME Volume 2 ISSUE Issue 1, Jan-June 2019
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<language>en-us</language>
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<title>International-Journal-of-Biomedical-Investigation-ISSUE VOLUME Volume 2 ISSUE Issue 1</title>
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		<title>Pharmacognostic-and-Phytochemical-Evaluation-of-Hibiscus-hirtus-Linn</title>
		<pubDate>21-Jun-2019</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/sxIBW8.pdf</link>
		<author>Radhika-B-Samreen-N-Ramya-N-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[The present initiative is to evaluate pharmacognostic characteristics and phytochemical evaluation of leaves of Hibiscus hirtus Linn. belonging to family Malvaceae. These studies give the information about Transverse Section (TS) of leaf and powder characters like xylem vessels, calcium oxalate crystals, and the quantitative microscopical characters like vein islet, vein termination, stomatal index. Physicochemical parameters like ash values and extractive values were determined. The results obtained from standardization of Leaves of Hibiscus hirtus Linn. give the details of microscopical, macroscopical and physicochemical characters which are useful in specifying standards. On the other hand, phytochemical examination gives the information about different phytoconstituents present in the herb. ]]>}</description>
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		<title>Acute-Eosinophilic-Leukemia-The-Challenges-of-Management-in-a-Resource-Poor-Setting</title>
		<pubDate>21-Jun-2019</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/wXxbR0.pdf</link>
		<author>Dapus-DO-Ochaka-EJ-Danjuma-JE</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Introduction: The diagnosis of certain subtypes of leukaemia is rarely made and descriptions in the literature are scantily found. Aim: This report aimed to describe a case of acute eosinophilic leukaemia, highlighting the management challenges in Jos.Case Report: A 36-year-old female tailor presented in the emergency and accident unit of the hospital with fever, epistaxis and menorrhagia. She was transfusion for anaemia before presentation. She was bleeding from the nose, pale and febrile. Full blood count revealed severe anaemia, thrombocytopenia and eosinophilic leucocytosis. Bone marrow aspiration (BMA) cytology showed myeloid hyperplasia with eosinophilic myeloblasts. Supportive hydration, blood transfusion, ant-microbial agents and allopurinol were administered. The patient was counselled and Daunorubicin and Cytosine arabinoside (DA) regimen was commenced. Evaluation on days 14 and 28 revealed only improvement in clinical and laboratory features. Induction of remission was embarked upon again with DA regimen. On day 14 of re-induction, the haemogram remained essentially the same. She was maintained on the regiment for eight cycles when symptoms of fever and mucosal bleeding (gum) resumed, accompanied by raised WBC, severe thrombocytopenia, neutropenia and anaemia.  She was on intravenous saline, fresh whole blood transfusion and antibiotic. Drugs regimen was changed to cyclophosphamide, vincristine, methotrexate and prednisolone. Conclusion: Rare forms of leukaemia when seen in the developing nations are faced with management limitations. ]]>}</description>
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		<title>Immune-Reconstitution-Disorders-Spotlight-on-Interferons</title>
		<pubDate>22-Jul-2019</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/avnR9b.pdf</link>
		<author>Mohei-H-Kellampalli-U-Vlasova-St-Louis-I</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Three decades of research in hematopoietic stem cell transplantation and HIV/AIDS fields have shaped a picture of immune restoration disorders. This manuscript overviews the molecular biology of interferon networks, the molecular pathogenesis of immune reconstitution inflammatory syndrome, and post- hematopoietic stem cell transplantation immune restoration disorders (IRD). It also summarizes the results of the assessment of diagnostic biomarkers of IRD, and tested targeted immunomodulatory treatments. ]]>}</description>
		</item><item>
		<title>Estriol-A-Ovarian-Hormones-Proconvulsant-Outcome-on-Kainic-Acid-Induced-Seizure-in-Mice</title>
		<pubDate>01-Jun-2024</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/Ghs7St.pdf</link>
		<author>Ahmad-A-Alam-MN-Najmi-AK-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Background: The estriol which was evaluated for its effect on Kainic acid kindling model of epileptogenesis in mice followed by evaluation on kindling-induced changes in cognitive and motor functions.Material and methods: Kindling was induced on every alternate day for duration of 45 days and treatment with Kainic acid was given at dose ranging from 15 to 30 mg/kg body weight intraperitoneal (i.p) and estriol was also administered at dosage of 0.005 and 0.1 mg/kg through i.p. After induction of kindling the seizure severity was recorded and further percentage incidence of animals kindled at the end of 45 days was also recorded. Spatial learning and cognitive alterations were assessed by Morris water test (MWT) while motor function was assessed by grip strength meter.Results: Estriol increased the rate of kindling in both the sexes of mice at great scale. Percentage incidence of seizures was also intensified. A noticeable decline in the grip strength, Morris water was observed following KA- kindling in pre-treated estriol groups of mice both the sexes.Conclusion: Control animals developed a seizure score of 4 after the end of 5 weeks, mice treated with estriol exhibited kindling in first two weeks only Clomiphene at dose of 0.9 mg/kg i.p. exhibited anticonvulsant effects. The study displayed that estriol has powerful proconvulsant effect. ]]>}</description>
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