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<title>International-Journal-of-Biomedical-Investigation-ISSUE VOLUME Volume 8 ISSUE Issue 1</title>
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International-Journal-of-Biomedical-Investigation: VOLUME Volume 8 ISSUE Issue 1, Jan-June 2025
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<title>International-Journal-of-Biomedical-Investigation-ISSUE VOLUME Volume 8 ISSUE Issue 1</title>
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		<title>Docking-studies-and-admetoxicity-parameter-of-azole-derivatives-for-antifungal-activity-</title>
		<pubDate>01-Oct-2025</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/x6hUL2.pdf</link>
		<author>Nagavalli-D-Abirami-G-Cheran-V-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[This study aims to perform molecular docking of various miconazole derivatives against antifungal proteins (8VLK and 4UYL) using ArgusLab and AutoDock. Additionally, MolInspiration software is utilized to predict the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties of these compounds. Azole derivatives are well-known antifungal agents that function by inhibiting ergosterol synthesis in the fungal cell membrane. Fifty miconazole derivatives have been identified using ChemSketch software, and their novelty has been confirmed through PubChem, ensuring that these compounds do not already exist. The study compares the binding energy of these derivatives with that of the original miconazole drug to identify potential candidates with lower energy, reduced toxicity, or enhanced antifungal potency.]]>}</description>
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		<title>Development-validation-and-pharmacological-evaluation-of-novel-134-oxadiazole-derivatives-for-anti-inflammatory-activity-</title>
		<pubDate>01-Oct-2025</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/6vOn7x.pdf</link>
		<author>Anand-R-Chourasiya-RK-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Inflammation underlies a wide spectrum of chronic diseases, prompting the search for novel, safer, and more efficacious anti-inflammatory agents. In this study, a new series of 1,3,4-oxadiazole derivatives was synthesized and evaluated for anti-inflammatory activity. An RP-HPLC method was developed and validated per ICH Q2(R1) guidelines to quantify the synthesized compounds. The analytical method demonstrated excellent specificity, linearity (R > 0.999), precision, and accuracy. Compounds A1 and A2 showed promising inhibition comparable to Diclofenac. Structural Activity Relationship (SAR) analysis indicated enhanced activity with electron-withdrawing substituents. These findings highlight the therapeutic potential of 1,3,4-oxadiazole derivatives and validate the developed HPLC method for routine application.]]>}</description>
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		<title>Intratumoral-microbiota-understanding-microbial-environment-of-tumors-</title>
		<pubDate>01-Oct-2025</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/RQ6gWL.pdf</link>
		<author>Priya-SS-Sruthi-G-Nandini-P-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Microorganisms within the human body are integral to numerous health and disease mechanisms. Studies demonstrate that several bacterial species are associated with multiple cancer forms. In addition to its role in cancer start and progression, the microbiome shows potential as a biomarker for cancer diagnosis, risk assessment, and prognosis determination. Intratumoral microorganisms significantly influence tumour biology by governing tumour initiation and progression, as well as altering responses to chemotherapy, radiation, and immunotherapy. A comprehensive understanding of the intratumoral microbiome's function in cancer necessitates additional research into its impacts and underlying mechanisms. This study examines the importance of intratumoral bacteria in cancer start, development, and metastasis, their influence on treatment results, and the methodologies utilized for profiling the intratumoral microbiome.]]>}</description>
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