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<title>International-Journal-of-Biomedical-Investigation-ISSUE VOLUME Volume 9 ISSUE Issue 1</title>
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<description>
International-Journal-of-Biomedical-Investigation: VOLUME Volume 9 ISSUE Issue 1, Jan-June 2026
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<title>International-Journal-of-Biomedical-Investigation-ISSUE VOLUME Volume 9 ISSUE Issue 1</title>
<link>http://ijbi.edwiserinternational.com/rss-feed.php</link>
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		<title>Gut-Microbial-Dysbiosis-in-Colorectal-Cancer-Insights-from-Shotgun-Metagenomic-Profiling-</title>
		<pubDate>26-Jan-2026</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/cawfnj.pdf</link>
		<author>Raghavendra-S-Pooja-M-and-Ramachandra-Prasad-LA-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Objective: Changes in the gut microbiome have been progressively associated with colorectal cancer (CRC), but there is still a dearth of population-specific metagenomic data.  The purpose of this work was to use shotgun metagenomic profiling to assess gut microbial dysbiosis linked to colorectal cancer and to find compositional changes that may have biological significance.Methods: The NCBI Sequence Read Archive's publically accessible colorectal cancer and healthy control dataset provided the stool shotgun metagenomic samples used in this investigation.  For analysis, a balanced selection of CRC and healthy control samples was chosen.  Quality control, host read removal, and taxonomy categorization using Kraken2 with Bracken-based abundance calculation were applied to sequencing reads to get microbiome profiles followed by Differential abundance analysis of the profiles which was carried out using the DESeq2 framework and microbial community diversity was evaluated using - and -diversity measures.Results: There was little indication of a decline in global diversity, and alpha-diversity indices revealed microbial richness and evenness that were nearly equal among CRC and control samples. However, a statistically significant variation in the overall community composition across groups was found using -diversity analysis. Differential abundance testing revealed a clear microbial signature associated withcolorectal cancer (CRC) samples in which opportunistic, pro-inflammatory and mucosa-associated taxa were observed to be significantly enriched and commensal beneficials such as Bifidobacterium sp. diminished. These findings suggested a significant restructuring of the gut microbiota rather than justan overall diversity decrease.Conclusion: Various alterations in gut microbiome composition were associated withcolorectal cancer. These changes reflected a consistent pattern characterized by reduction of saccharolytic commensals and increase in taxaimplicated with anaerobic and proteolytic metabolism which could be candidate microbiome-based biomarkers for CRC.]]>}</description>
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		<title>Phytoliposome-Based-Targeted-Drug-Delivery-in-Tuberculosis-Therapy-A-Comprehensive-Review-</title>
		<pubDate>13-May-2026</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/msdqhS.pdf</link>
		<author>Mandal-RK-Pandey-A-Priya-M-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Tuberculosis remains a major global health burden, further complicated by prolonged treatment regimens, poor patient adherence and the emergence of multidrug-resistant strains. These challenges highlight the urgent need for advanced drug delivery approaches. The present review aims to evaluate the potential of phytoliposome based targeted drug delivery systems in improving TB therapy. A comprehensive narrative review methodology was adopted, analyzing literature published between 2010 to 2025 from scientific databases including PubMed, Scopus and Google Scholar. Phytoconstituents such as alkaloids, flavonoids and terpenoids exhibit significant antimycobacterial activity but suffer from poor bioavailability and pharmacokinetic limitations. Phytoliposomes, formed by complexation of phytochemicals with phospholipids, enhance solubility, stability and intracellular delivery, particularly to macrophages harbouring Mycobacterium tuberculosis. Key findings indicate a 2-5 fold improvement in drug efficacy, enhanced bioavailability, controlled release and reduced systemic toxicity. Targeted delivery strategies including ligand-mediated systems, further improve therapeutic outcomes and reduce drug resistance. In conclusion, phytoliposome based drug delivery systems represent a promising and innovative approach for TB management. Their ability to enhance drug performance and enable targeted therapy suggests strong potential for future clinical applications, particularly in addressing resistant and latent TB infections.]]>}</description>
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		<title>Biogenic-Metallic-Nanoparticles-Derived-from-Agricultural-and-Biowaste-for-Advanced-Wound-Healing-Applications-Mechanisms-Therapeutic-Potential-Challenges-and-Future-Perspectives-</title>
		<pubDate>01-Jul-2026</pubDate>
<link>http://ijbi.edwiserinternational.com/admin/uploads/Sm03cV.pdf</link>
		<author>Fazal-B-Karim-MJ-Dasgupta-D-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Chronic and non-healing wounds remain a major global healthcare challenge owing to persistent microbial infections, prolonged inflammation, oxidative stress, impaired angiogenesis, and increasing antimicrobial resistance. Conventional wound management strategies often provide suboptimal outcomes, necessitating the development of multifunctional and sustainable therapeutic approaches. Green-synthesized metallic nanoparticles derived from agricultural and food-processing waste have emerged as promising biomaterials because of their eco-friendly production, cost-effectiveness, and broad spectrum of biological activities. Agricultural residues are rich in bioactive phytochemicals, including polyphenols, flavonoids, proteins, carbohydrates, and organic acids, which act as natural reducing, stabilizing, and capping agents during nanoparticle synthesis. Metallic nanoparticles such as silver, gold, zinc oxide, copper oxide, iron oxide, titanium dioxide, and magnesium oxide exhibit potent antimicrobial, antioxidant, anti-inflammatory, angiogenic, and regenerative properties that collectively promote wound repair. These nanoparticles facilitate healing by disrupting microbial membranes, modulating inflammatory cytokines, regulating oxidative stress, enhancing fibroblast proliferation, stimulating keratinocyte migration, promoting collagen deposition, and accelerating extracellular matrix remodeling and angiogenesis. Despite encouraging preclinical evidence, challenges including variability in biological precursors, reproducibility of green synthesis, long-term biosafety, large-scale manufacturing, and regulatory approval continue to limit clinical translation. This review summarizes recent advances in agricultural waste-mediated green synthesis of metallic nanoparticles, their physicochemical characteristics, mechanisms of wound healing, biomedical applications, safety considerations, and translational challenges, while highlighting their potential to integrate sustainable nanotechnology with circular bioeconomy principles for the development of next-generation wound care systems.]]>}</description>
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