Volume 2 ; Issue 1 ; in Month : Jan-June (2019) Article No : 119
Mohei H, Kellampalli U, Vlasova-St. Louis I

Abstract

Three decades of research in hematopoietic stem cell transplantation and HIV/AIDS fields have shaped a picture of immune restoration disorders. This manuscript overviews the molecular biology of interferon networks, the molecular pathogenesis of immune reconstitution inflammatory syndrome, and post- hematopoietic stem cell transplantation immune restoration disorders (IRD). It also summarizes the results of the assessment of diagnostic biomarkers of IRD, and tested targeted immunomodulatory treatments.

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