Berberine verses Sorafenib for the treatment of Hepatocellular carcinoma
Volume 3 ; Issue 1 ; in Month : Jan-June (2020) Article No : 125
Phiri M, Duo L, Tengfei L, et al.
Abstract
Traditional Chinese medicine as Complimentary Alternative Medicine (CAM) is useful in the treatment of chronic diseases including Cancer. Studies have shown components in plants responsible for their synergic effect and, analysis has revealed multiple components of plants that work synergistically to produce useful toxic effect against hepatocellular carcinoma of which a single conventional drug cannot produce. Different types of medicines have been discovered for HCC, but, a compiled quantitative analysis of these compounds will influence clinicians and researchers decisions about their use, research methodology to yield new drugs and most importantly, it can reduce research cost and time. 80% of the general population in the world are using plants to treat several illnesses and about 25% of the drugs prescribed worldwide come from plants. Sorafenib has been the drug of choice for over 10 years for the treatment of Hepatocellular Carcinoma patients of which Berberine a Traditional Chinese Medicine has also shown to be effective. This review in campuses articles obtained from western and Chinese journal data base. In conclusion, TCM has a vast number of components that can be used as alternative novel compounds in cancer treatment. Alkaloid Berberine has components that can be utilized to circumvent Hepatocellular Carcinoma when used in combination.
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