Dostarlimab “A Miracle Drug Against Cancer”: Current Knowledge and On-going Clinical Trials
Volume 5 ; Issue 1 ; in Month : Jan-June (2022) Article No : 140
Jahangir MA, Kumar N, Shahab MS
Cancer stands as one of the leading causes of death globally. Its socio-economic burden is increasing day by day. There is no defined treatment strategy for cancer. In most of the cases a combinatorial therapy approach is utilised which includes surgery, chemotherapy, immune therapy, radiation therapy etc. Immune checkpoints are a revolutionary discovery in cancer immunotherapy. Dostarlimab is an anti-programmed cell death protein-1 (PD-1) immunoglobulin G4 (IgG4) humanised monoclonal antibody (mAb), produced by recombinant DNA technology in mammalian Chinese hamster ovary (CHO) cells. PD-1 is an immune checkpoint receptor expressed by T-cells which has shown to suppress cancer-specific immune responses. In this article we provide the recent known information regarding dostarlimab along with currently undergoing 44 clinical trials globally with its title, conditions, interventions, and outcome measures.
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