Volume 2 ; Issue 1 ; in Month : Jan-June (2019) Article No : 116a
Ahmad A, Alam MN, Najmi AK, et al.

Abstract

Background: The estriol which was evaluated for its effect on Kainic acid kindling model of epileptogenesis in mice followed by evaluation on kindling-induced changes in cognitive and motor functions. Material and methods: Kindling was induced on every alternate day for duration of 45 days and treatment with Kainic acid was given at dose ranging from 15 to 30 mg/kg body weight intraperitoneal (i.p) and estriol was also administered at dosage of 0.005 and 0.1 mg/kg through i.p. After induction of kindling the seizure severity was recorded and further percentage incidence of animals kindled at the end of 45 days was also recorded. Spatial learning and cognitive alterations were assessed by Morris water test (MWT) while motor function was assessed by grip strength meter. Results: Estriol increased the rate of kindling in both the sexes of mice at great scale. Percentage incidence of seizures was also intensified. A noticeable decline in the grip strength, Morris water was observed following KA- kindling in pre-treated estriol groups of mice both the sexes. Conclusion: Control animals developed a seizure score of 4 after the end of 5 weeks, mice treated with estriol exhibited kindling in first two weeks only Clomiphene at dose of 0.9 mg/kg i.p. exhibited anticonvulsant effects. The study displayed that estriol has powerful proconvulsant effect.

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