Volume 8 ; Issue 1 ; in Month : Jan-June (2025) Article No : 159
Anand R, Chourasiya RK.

Abstract

Inflammation underlies a wide spectrum of chronic diseases, prompting the search for novel, safer, and more efficacious anti-inflammatory agents. In this study, a new series of 1,3,4-oxadiazole derivatives was synthesized and evaluated for anti-inflammatory activity. An RP-HPLC method was developed and validated per ICH Q2(R1) guidelines to quantify the synthesized compounds. The analytical method demonstrated excellent specificity, linearity (R² > 0.999), precision, and accuracy. Compounds A1 and A2 showed promising inhibition comparable to Diclofenac. Structural Activity Relationship (SAR) analysis indicated enhanced activity with electron-withdrawing substituents. These findings highlight the therapeutic potential of 1,3,4-oxadiazole derivatives and validate the developed HPLC method for routine application.

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